王宜冰
发布人:2020十大正规网赌网址网站管理员  发布时间:2019-02-26   动态浏览次数:1850


王宜冰



食品科学专业:硕士生导师

王宜冰,讲师,理学博士,国家纳米科学中心和北京大学前沿交叉学科研究院联合培养研究生。20129月加入全球十大网赌排行app,开展纳米生物技术在食品安全、生物医药、环境保护等领域的应用研究。借助扫描探针显微技术开展多肽组装、生物分子界面作用、生物界面微纳结构的相关基础研究。开发了多种靶标的亲和多肽筛选技术并实现创新应用。目前累计发表一作及通讯作者文章20余篇,申请发明专利10余项,授权3项。

 

研究方向:

蛋白质、多肽、多糖的生物基材料开发及在食品及医药领域的应用;

天然活性多肽的结构与生物学功能;

基于扫描探针显微技术的纳微结构研究;

食品安全检测与防控。

 

主持或参加的科研项目或基金:

上海市自然科学基金面上项目,生物被膜相关淀粉样蛋白的胞外聚集机制与调控,2019/7-2022/620万元,在研,主持;

国家自然科学基金青年基金面上项目,多肽对纳米颗粒的识别性亲和及其在组装生物功能纳米结构中的应用研究,2014/1-2016/1225万元,结题,主持;

华东理工大学基本科研业务费,抗体-亲和肽-纳米颗粒(scFv-SBP-MSN)靶向型药物载体的组装规律及其与细胞的作用机制,2015/11-2017/1216万元,结题,主持;

横向项目(万华化学集团),生物酶在乳化液环境中活性与稳定性测试与优化,2017/10-2018/1010万,结题,主持;

国家自然科学基金面上项目,靶向性活性大分子用于食品生物污染控制的研究,2015/1-2018/1284万元,结题,骨干。

 

教学:

食品生物技术,本科生;

食品工艺学实验,本科生;

生物学论文abc,本科生;

能源生物技术,本科生。

 

代表性论文(*通讯作者):  

1.  Qize Xuan, Jiaxin He, Min Li, Ruoshi Chai, Chenxuan Wang*, Yibing Wang*, Ping Wang. Monomer-Targeting Affinity Peptide Inhibitors of Amyloid with No Self-Fibrillation and Low Cytotoxicity. Chemical Communications, 2020, 56, 1633–1636.

2. Fan Shi, Lingfeng Gan, Yibing Wang*, Ping Wang. Impedimetric Biosensor Fabricated with Affinity Peptides for Sensitive Detection of Escherichia coli O157:H7. Biotechnology Letters, 2020, 45, 825–832.

3.  Hao Dong, Wenxue Zhang, Yibing Wang*, Dong Liu*, Ping Wang. Biofilm polysaccharide display platform: A natural, renewable, and biocompatible material for improved lipase performance. Journal of Agricultural and Food Chemistry, 2020, 68, 1373–1381.

4.  Lingfeng Gan, Chao Chen, Peng Qin, Yibing Wang*, Ping Wang*. Silver nanoparticle-functionalized polydopamine nanotubes for highly sensitive nanocomposite electrode sensors. Journal of Electroanalytical Chemistry, 2020, 861, 113961.

5.  Wen Sun#, Yibing Wang#, Wenxue Zhang, Hanjie Ying*, Ping Wang*. Novel design of a surfactant peptide for removal of biofilms. Colloids and Surfaces B: Biointerfaces, 2018, 172, 180–186. 

6.  Wenfeng Zhu#, Yibing Wang#, Dan Xie, Linxiu Cheng, Ping Wang, Qingdao Zeng*, Min Li*, Yuliang Zhao. In Situ Monitoring the Aggregation Dynamics of Amyloidβ Protein Aβ42 in Physiological Media via a Raman-Based Frequency Shift Method. ACS Applied Bio Materials, 2018, 1(3), 814–824.

7.   Qingyu Chen#, Liwei Zhang#, Yonghai Feng*, Fan Shi, Yibing Wang*, Ping Wang, Lei Liu*. Dual-functional peptide conjugated gold nanorods for the detection and photothermal ablation of pathogenic bacteria. Journal of Materials Chemistry B, 2018, 6, 7643–7651.

8. Chao Chen, Wen Sun, Hangya Lv, Hui Li, Yibing Wang*, Ping Wang*. Spacer Arm-facilitated tethering of laccase on magnetic polydopamine nanoparticles for efficient biocatalytic water treatment. Chemical Engineering Journal, 2018, 350, 949–959.

9.  Chao Chen, Wen Sun, Xiaoli Wang, Yibing Wang*, Ping Wang*. Rational design of curcumin loaded multifunctional mesoporous silica nanoparticles to enhance the cytotoxicity for targeted and controlled drug release. Materials Science and Engineering C-Materials for Biological Applications, 2018, 85, 88–96. 

10. Xiaoxing Chen#,Yibing Wang#, Ping Wang*. Peptide-Induced Affinity Binding of Carbonic Anhydrase to Carbon Nanotubes. Langmuir, 2015, 31, 397–403. 

11. Yibing Wang#,Yibao Li#,Yin Luo, Meng Xu, Xuemei Zhang, Yuanyuan Guo, Guanghong Wei*, Lihua Yuan*, Bing Gong, Yanlian Yang*, Chen Wang. Study on Molecular Cavity of Oligoamide Macrocycles by Using Scanning Tunneling Microscopy.ChemPhysChem, 2012, 13(16), 3598–3604.   

12. Yibing Wang#,Lin Niu#,Yibao Li, Xiaobo Mao, Yanlian Yang*, Chen Wang*. Single Molecule Studies of Cyclic Peptides Using Molecular Matrix at Liquid/Solid Interface by Scanning Tunneling Microscopy. Langmuir, 2010, 26(21), 16305–16311.  

13. Xiaobo Mao#,Yibing Wang#,Lei Liu, Lin Niu, Yanlian Yang*, Chen Wang*. Molecular-Level Evidence of the Surface-Induced Transformation of Peptide Structures Revealed by Scanning Tunneling Microscopy. Langmuir, 2009, 25(16), 8849–8853.

 

 

发明专利:

1.      壳聚糖亲和七肽及其筛选方法和应用。王宜冰,于勇,姚文基,王平。中国专利公开号:CN 106518968 B,授权日:2019-11-08

2.      大肠杆菌O157H7亲和十二肽及其筛选方法和应用。王平,王宜冰,施凡,孙文,甘凌风,王超勇,刘晓骏。中国专利公开号:CN 106565826 A,授权日:2020-2-3

3.      靶向微生物生物被膜的表面活性剂样多肽及其制备方法和应用。王平,王宜冰,孙文。中国专利公开号:CN 109867711 A 

4.      淀粉样蛋白纤维与单体的亲和多肽的筛选方法及其在生物传感中的应用。王宜冰,王平,甘凌风,姚文基。中国专利申请号:201810953194.5

5.      一种Amylin亲和多肽及其应用。王宜冰,玄起泽,赫佳鑫。中国专利公开号:CN 110240632 A 

 

 

 

 

联系方式:

办公室:华东理工大学实验181413

电话:021-64250135

通讯:上海市徐汇区梅陇路130号,邮编:200237 

E-mail: ybwang@ecust.edu.cn