刘雪婷
发布人:2020十大正规网赌网址网站管理员  发布时间:2018-03-29   动态浏览次数:9897

刘雪婷


生物工程专业:博士生导师/硕士生导师

  

生物化学与分子生物学:博士生导师/硕士生导师

  

生物工程领域:工程硕士生导师


 

刘雪婷,理学博士,教授。

1999年毕业于中国药科大学中药制药专业,获得理学学士学位(师从罗厚蔚教授和丁林生教授)。2006年毕业于中国药科大学药物化学专业,获理学博士学位(师从闵知大教授和梁敬钰教授),同年进入中科院上海有机化学研究所从事博士后研究工作(师从俞飚教授),并于2007-2010期间在美国威斯康辛大学进行博士后研究(师从Aaron Monte教授)。

201010月回国加入中科院微生物研究所成为副研究员,于201606月受聘成为教授,引进到全球十大网赌排行app工作。期间于2012年获得中国科学院公派出国留学,在美国加州大学圣地亚哥分校合作研究6个月(合作导师Pieter Dorrestein教授),并于2017年获得国家留学基金委资助,在波士顿大学进行合作研究一年(合作导师刘平华教授)。

研究成果发表SCI论文50余篇,包含通讯作者或第一作者论文(含共同)发表在Angew Chem, Nat Prod Rep, Org Lett, Appl Microbiol Biotechnol等期刊上;发表合作文章在Nat Biotechnol, Org Lett等期刊上。获得授权专利8件。主持国家重点研发计划子课题1项、自然科学基金面上项目1项;主持完成自然科学基金面上项目和基金青年项目各1项、十二五“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项子课题1项;主持横向项目2项;参加国际抗结核联盟的合作研究项目1项和欧盟第七框架计划“Pharma Sea”项目1项。



研究方向:

1. 微生物来源的活性天然产物研究

采用基因组生物信息学分析和多种谱学分析手段为导向,快速发现和鉴定微生物来源(包括放线菌和真菌)的新颖活性天然产物。

2. 利用合成生物学策略合成“非天然”的活性天然产物

运用合成生物学或系统生物学策略,扩大活性天然产物结构多样性。



主持和参加的科研项目:

  1. 国家重点研发计划子课题负责人(425万元) 2020.01-2024.12

  2. 主持中国自然科学基金面上基金项目(63万元) 2020.01-2023.12

  3. 主持企业横向项目(100万元)2018.09-2019.08

  4. 主持华理-企业共建联合实验室(300万元)2018.09-2021.08

  5. 主持中央高校基本科研业务费研究基金(400万元)2016-2017

  6. 主持中国自然科学基金面上基金项目(64万元)2016.01-2019.12

  7. 主持十二五“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项子课题(399万元)2013.01-2015.12

  8. 主持国家自然科学青年基金项目(20万元)2012.01-2014.12

  9. 主持国家自然科学国际(地区)合作与交流项目(6万元)2013.01-2013.07

  10. 参加欧盟第七框架研究计划 2012.10-2016.10

  11. 参加盖茨基金会-全球结核病药物研发联盟项目 2009.01-2012.12



教学:

  1. 主讲研究生专业选修课,合成生物学与天然产物药物发现(全英文),32学时,2学分。

  2. 主讲本科生选修课,化学生物学,32学时,2学分。



代表性论文(*通讯作者):

2019:

  1. Jianying Han, Jingyu Zhang, Zhijun Song, Miaomiao Liu, Jiansen Hu, Chengjian Hou, Guoliang Zhu, Lan Jiang, Xuekui Xia, Ronald J. Quinn, Yunjiang Feng, Lixin Zhang*, Tom Hsiang*, Xueting Liu*. Genome- and MS-based mining of antibacterial chlorinated chromones and xanthones from the phytopathogenic fungus Bipolaris sorokiniana strain 11134. Appl. Microbiol. Biotechnol., 2019, 103, 5167-5181.

  2. Jingyu Zhang, Zhenzhen Wang, Zhijun Song, Loganathan Karthik, Chengjian Hou, Guoliang Zhu, Lan Jiang, Jianying Han, Rong Ma, Li Li, Lixin Zhang*, Xueting Liu*, Tom Hsiang*. Brocaeloid D, a novel compound isolated from a wheat pathogenic fungus, Microdochium majus 99049. Synth. Syst. Biotechnol., 2019, 4, 173-179.

  3. Jingyu Zhang, Bixiao Li, Yujie Qin, Loganathan Karthik, Guoliang Zhu, Chengjian Hou, Lan Jiang, Miaomiao Liu, Xin Ye, Mei Liu, Tom Hsiang, Huanqin Dai*, Lixin Zhang*, and Xueting Liu*. A new abyssomicin polyketide with anti-influenza A virus activity from a marine-derived Verrucosispora sp. MS100137. Appl. Microbiol. Biotechnol., 2019, in press.

2018:

  1. Shu-Shan Gao, Nathchar Naowarojna, Ronghai Cheng, Lixin Zhang, Xueting Liu*. and Pinghua Liu*. Recent Examples of -Ketoglutarate-Dependent Mononuclear Non-Haem Iron Enzymes in Natural Product Biosyntheses. Nat. Prod. Rep., 2018, 35, 792-837.

  2. Xiangyang Liu, Feng Xie, Leah B. Doughty, Qi Wang, Lixin Zhang, Xueting Liu*, Yi-Qiang Cheng*. Genomics-guided discovery of a new and significantly better source of anticancer natural drug FK228. Synth. Syst. Biotechnol., 2018, 3, 268-274.

2017

  1. Wenni He, Yao Li, Yuejie Qin, Xiaomei Tong, Zhijun Song, Yu Zhao, Ran Wei, Li Li, Huanqin Dai, Wenzhao Wang, Houwei Luo, Xin Ye, Lixin Zhang*, Xueting Liu*. New cryptotanshinone derivatives with anti-influenza A virus activities obtained via biotransformation by Mucor rouxii. Appl. Microbiol. Biotechnol., 2017, 101(16), 6365-6374.

  2. Mei Liu, Pei Huang, Qian Wang, Biao Ren, Oyeleye A, Mei Liu, Jian Zhang, Li X, Zhang X, Lixin Zhang*, Xueting Liu*. Synergistic antifungal indolecarbazoles from Streptomyces sp. CNS-42 associated with traditional Chinese medicine Alisma orientale. J. Antibiot. (Tokyo). 2017 May;70(5):715-717.

2016

  1. Wael M. Abdel-Mageed*, Soad A. L. Bayoumi, Lamya H. Al-wahaibi, Li Li, Hanaa M. Sayed, Mohamed S. A. Abdelkader, Ali A. El-Gamal, Mei Liu, Jingyu Zhang, Lixin Zhang*, and Xueting Liu*. Noncyanogenic Cyanoglucoside Cyclooxygenase Inhibitors from Simmondsia chinensis. Org. Lett., 2016, 18(8), 1728-1731. (IF = 6.579)

  2. Pei Huang, Feng Xie, Biao Ren, Qian Wang, Jian Wang, Qi Wang, Wael M. Abdel-Mageed, Mei Liu, Jianying Han, Ayokunmi Oyeleye, Jinzhao Shen, Fuhang Song, Huanqin Dai, Xueting Liu*, Lixin Zhang*. Anti-MRSA and anti-TB Metabolites from Marine-derived Verrucosispora sp. MS100047. Appl. Microbiol. Biotechnol., 2016, 100(17), 7437-7347.

  3. Wenni He, Miaomiao Liu, Xiaolin Li, Xiaoping Zhang, Wael M. Abdel-Mageed, Li Li, Wenzhao Wang, Jingyu Zhang, Jianying Han, Huanqin Dai, Ronald J. Quinn, Hung-wen Liu, Houwei Luo, Lixin Zhang*, Xueting Liu*. Fungal biotransformation of tanshinone results in [4+2] cycloaddition with sorbicillinol: Evidence for enzyme catalysis and increased antibacterial activity. Appl. Microbiol. Biotechnol., 2016, 100(19), 8349-8357.

  4. Wenni He, Miaomiao Liu, Pei Huang, Wael M. Abdel-MageedJianying HanJeramie D. WatrousDon D. NguyenWenzhao WangFuhang Song, HuanqinDaJingyu ZhangRonald J. QuinnTanja GrkovHouwei LuoLixin Zhang*Xueting Liu*. Discovery of tanshinone derivatives with anti-MRSA activity via targeted bio-transformation. Synth. Syst. Biotechnol., 2016, 1(3), 187-194.

  5. Miaomiao Liu, Tanja Grkovic, Lixin Zhang, Xueting Liu*, Ronald J Quinn*. A model to predict anti-tuberculosis activity: value proposition for marine microorganisms. J. Antibiot. (Tokyo), 2016, 69(8), 594-599.

2015:

  1. Nadia H. Mohamedab, Miaomiao Liu, Wael M. Abdel-Mageed, Lamya H. Alwahibi, Huanqin Dai, Mady Ahmed Ismail, Gamal Badr, Ronald J. Quinne, Xueting Liu*, Lixin Zhang*, Ahmed A. M. Shoreit.* Cytotoxic cardenolides from the latex of Calotropis procera. Bioorg. Med. Chem. Lett., 2015, 25(20), 4615-4620.

  2. Ren, B. #, Huang, P.#, Zhang J., He W., Han J., Xueting Liu*, and Lixin Zhang*. Chapter 2 “Main applications of antibiotics”, Antibiotics: Current Innovations and Future Trends, 2015, Caister Academic Press, Norfolk, U.K.

  3. Jianying Han, Jingyu Zhang, Wenni He, Pei Huang, Ayokunmi Oyeleye, Xueting Liu*, and Lixin Zhang*. Bioassay-guided Identification of Bioactive Molecules from Traditional Chinese Medicines. Chemical Biology--Methods and Protocols. Springer. 2015, 187-196.

  4. Jingyu Zhang, Jianying Han, Ayokunmi Oyeleye, Miaomiao Liu, Xueting Liu*, and Lixin Zhang*. Extraction methods of natural products from Traditional Chinese Medicines. Chemical Biology--Methods and Protocols. Springer. 2015, pp 177-185.

2014:

  1. Miaomiao Liu, Wael M. Abdel-Mageed, Biao Ren, Wenni He, Pei Huang, Xiaolin Li, Krishna Bolla, Hui Guo, Caixia Chen, Fuhang Song, Huanqin Dai, Tanja Grkovic, Xiaoping Zhang,* Xueting Liu,* Lixin Zhang*. Antitubercular Pluramycins from Endophytic Streptomyces sp. Y3111. Appl. Microbiol. Biotechnol., 2014, 98(3), 1077-1085.

  2. Xiaolin Li, Pei Huang, Qian Wang, Lie Xiao, Miaomiao Liu, Krishna Bolla, Bo Zhang, Linyong Zheng, Bingcheng Gan, Xueting Liu*, Lixin Zhang,* Xiaoping Zhang.* Staurosporine from the endophytic Streptomyces sp. strain CNS-42 acts as a potential biocontrol agent and growth elicitor in cucumber. Antonie van Leeuwenhoek, 2014, 106 (3), 515-525.

2013:

  1. Qian Wang, Fuhang Song, Xue Xiao, Pei Huang, Li Li, Aaron Monte, Wael M. Abdel-Mageed, Jian Wang, Hui Guo, Wenni He, Feng Xie, Huanqin Dai, Miaomiao Liu, Caixia Chen, Hao Xu, Mei Liu, Andrew M. Piggott, Xueting Liu*, Robert J. Capon*, Lixin Zhang*. Abyssomicins from a South China Sea deep-sea sediment Verrucosispora sp.: Natural thioether Michael addition adducts as potential antitubercular prodrugs. Angew. Chem. Int. Ed. Engl., 2013, 52, 1231-1234.

  2. Jingyu Zhang, Wael M. Abdel-Mageed, Miaomiao Liu, Pei Huang, Wenni He, Li Li, Fuhang Song, Huanqin Dai, Xueting Liu*, Jingyu Liang*, Lixin Zhang*. Caesanines A-D, new cassane diterpenes with unprecedented N bridge from Caesalpinia sappan. Org. Lett., 2013, 15 (18), 4726-4729.

  3. Xueting Liu and Lixin Zhang*. Tanshinones against cancer and cardiovascular diseases and their biosynthesis. Handbook of Natural Products, 2013, chapter III.

  4. Qi Wang, Biao Tang, Lifu Song, Biao Ren, Qun Liang, Feng Xie, Ying Zhuo, Xueting Liu*, Lixin Zhang*. 3DScapeCS: application of three dimensional, parallel, dynamic network visualization in Cytoscape. BioMed Central, 2013, 14, 322. doi: 10.1186/1471-2105-14-322.

2012

  1. Xue-Ting Liu, William R. Schwan, Thomas J. Volk, Marc Rott, Miaomiao Liu, Pei Huang, Zhong Liu, Ying Wang, Nicholas C. Zitomer, Cassandra Sleger, Scott Hartsel, Aaron Monte,* Lixin Zhang*. Antibacterial Spirobisnaphthalenes from the North American Cup Fungus, Urnula craterium. Journal of Natural Products, 2012, 75, 1534-1538.

  2. Xueting Liu, Caixia Chen, Wenni He, Pei Huang, Miaomiao Liu, Qian Wang, Hui Guo, Krishna Bolla, Yan Lu, Fuhang Song, Huanqin Dai, Mei Liu, and Lixin Zhang. Exploring anti-TB leads from natural products library originated from marine microbes and medicinal plants. Antonie van Leeuwenhoek, 2012, 102, 447-451.

  3. Xueting Liu, Bolla Krishna, Elizabeth Jane Ashforth, Ying Zhuo, Hong Gao, Pei Huang, Stanley SA, DT Hung, Lixin Zhang*. Antonie van Leeuwenhoek, 2012, 101, 55-66.

2006-2010

  1. Xue-Ting Liu, Abby L. Winkler, Marc Rott, Thomas J. Volk, William R. Schwan, Aaron Monte*. Antibacterial compounds from mushrooms II: lanostane triterpenoids and an ergostane steroid with activity against Bacillus cereus isolated from Fomitopsis pinicola. Planta Med., 2010, 76(5), 464-466.

  2. Xue-Ting Liu, Abby L. Winkler, Marc Rott, Thomas J. Volk, William R. Schwan, Aaron Monte*. Antibacterial compounds from mushrooms I: Lanostane-type triterpene and prenylphenol derivatives from Jahnoporus hirtus and Albatrellus flettii and their activities against Bacillus cereus. Planta Med., 2010, 76(2), 182-185.

  3. Xue-Ting Liu*, Zhen-Zhong Wang, Wei Xiao, Hui-Wu Zhao, Jie Hu, Biao Yu*. Cholestane Glycosides Trihydroxy Fatty Acids from the Rhizomes of Dioscorea septemloba. Planta Med., 2010, 76(3), 291-294.

  4. Xue-Ting Liu*, Zhen-Zhong Wang, Wei Xiao, Hui-Wu Zhao, Jie Hu, Biao Yu*. Cholestane and Spirostane Glycosides from the Rhizomes of Dioscorea septemloba. Phytochemistry, 2008, 69(6), 1411-1418.

  5. Xue-Ting Liu, Yao Shi, Biao Yu, Ian D. Williams, Herman H-Y Sung, Qiong Zhang, Jing-Yu Liang, Nancy Y. Ip, Zhi-Da Min*. Antibacterial diterpenoids from Sagittaria pygmaea. Planta Med., 2007, 73 (1), 84-90.

  6. Xue-Ting Liu, Qin Pan, Yao Shi, Ian D. Williams, Herman H.-Y. Sung, Qiong Zhang, Jing-Yu Liang, Nancy Y. Ip, and Zhi-Da Min*. ent-Rosane and Labdane Diterpenoids from Sagittaria sagittifolia and Their Antibacterial Activity against Three Oral Pathogens. J. Nat. Prod., 2006, 69, 255-260.



发明专利:

  1. 张立新,宋福行,陈彩霞,王倩,郭徽,傅成章,代焕琴,刘雪婷,谢峰,杨娜,余珂。一株链霉菌及其在生产棘霉素中的应用,专利号ZL 201110366624.1 (授权公告日:20121219日 )。

  2. 张立新,宋福行,陈彩霞,郭徽,傅成章,代焕琴,刘雪婷,谢峰,杨娜,余珂,王倩。一株链霉菌及其在生产放线菌素中的应用。专利号:ZL201110366034.9 (授权公告日:2013116日)。

  3. 张立新,宋福行,陈彩霞,任彪,刘雪婷,代焕琴,郭徽,杨娜。一种抗真菌的药物组合物。专利号:ZL201210245954.X (授权公告日:20131023日)

  4. 张立新,刘雪婷,亚伦 蒙蒂,尼古拉斯 齐特默,蓝苑元 威廉 斯沃恩, 汤姆 沃克,代焕琴,陈彩霞。抗多种耐药菌化合物及其制备方法与应用。专利号:ZL201110436175.3(授权公告日:201425日)

  5. 张立新,宋福行,陈彩霞,郭徽,刘雪婷,代焕琴。抗肿瘤化合物及其制备方法与应用。授权号:ZL201210067370.8 (授权公告日:201464日)

  6. 张立新、梁敬钰、张敬宇、刘雪婷、刘苗苗。一种抗菌化合物及其制备方法与应用。专利号:ZL 201310378741.9 (授权公告日:2015527日)

  7. 张立新,刘雪婷,王倩,宋福行,陈彩霞,王剑,郭徽,代焕琴,黄佩。来源于海洋疣孢菌的多环聚酮类化合物及其制备方法与应用。专利号:ZL201210079317.X (授权公告日:2015617日)

  8. 张立新,何文妮,刘雪婷等。一种真菌转化的抗菌活性物质及其制备方法与应用。专利号:ZL20151016433. (授权公告日:201697日)





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