万民熙
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 万民熙


生物工程专业:硕士生导师


万民熙,19819月出生于湖南衡阳,中南大学和美国Johns Hopkins University联合培养博士。入选云南省青年千人计划(柔性引才,2018)、华东理工大学青年英才引进与培育计划(2015)、全球十大网赌排行app青年交叉创新提升计划(青椒计划,2020)。近十年来,一直从事微藻生物技术、合成生物学和光生物反应器方面的研究工作。已在生物技术领域相关期刊上公开发表SCI等各类论文43篇;申请发明专利11项。担任科技核心期刊《现代生物医学进展》编委,以及Bioresource TechnologyAlgae Research等国际期刊审稿人。

一、教育经历

2007/9 - 2012/6,中南大学,微生物系,博士

2010/1 - 2012/1Johns Hopkins UniversityDepartment of Chemical and Biomolecular Engineering,联合培养博士

2004/9 - 2007/7,中南大学,生物工程系,硕士

1999/9 - 2003/7,中南大学,化学工程系,学士

二、工作经历

2019/8 - 至今,华东理工大学,生物工程学院,副教授

2016/7 - 至今,华东理工大学,生物工程学院,硕士生导师

2012/7 - 2019.7,华东理工大学,生物工程学院,师资博士后、讲师

 

研究方向:

[1] 微藻生物技术:以微藻高价值物质为目的产物的生产工艺开发、分子生物学研究、代谢途径改造等。

[2] 合成生物学:主要以微藻为底盘生物,开发高效细胞工厂合成目的产物。

[3] 光生物反应器:用于光合微生物的高效反应器的研制与产业化

 

主持或参加的科研项目或基金:

作为负责人主持9个项目/课题。

[1] 国家重点研究计划先进技术专项课题一项(国拨经费157万)

[2] 国家高技术研究发展计划863课题高产虾青素的雨生红球藻异养-稀释-光诱导串联培养新工艺的优化与工业化放大(国拨经费750万,自筹经费800万)

[3] 国家重点基础研究发展计划973项目微藻能源规模化制备的科学基础”-基于光照方向混合及光衰减特性的光生物反应器设计与放大原理子课题光生物反应器热模验证——雨生红球藻培养工艺优化与放大研究

[4] 国家自然科学基金青年科学基金项目雨生红球藻厚壁孢子形成对虾青素合成的相关基因转录调控的影响机制

[5] 云南省青年千人计划课题裸藻工业化生产技术的开发与产业化,(云南省拨经费70万)

[6]全球十大网赌排行app2020 年度青年交叉创新提升计划(青椒计划)项目,异养过程中剪切力对裸藻细胞的伤害机制及其调控

[7] 中国博士后基金,特别资助雨生红球藻厚壁孢子形成与虾青素合成调控的关联机制

[8] 中国博士后面上项目,一等资助雨生红球藻异养-光诱导串联培养中细胞形态调控研究

[9] 中央高校基本科研业务费-探索研究基金雨生红球藻细胞形态转变规律与分子机制及其在细胞培养中的应用

 

教学:

主讲本科生公选课程《微藻生物技术导论》,合讲本科生课程《海洋生化工程概论》、《海洋生物技术》和研究生课程《海洋生化工程》。

 

代表性论文(*通讯作者):  

[1]       Lei Fang, Jingkui Zhang, Zhongnan Fei, Minxi Wan*(通讯作者), Astaxanthin accumulation difference between non-motile cells and akinetes of Haematococcus pluvialis was affected by pyruvate metabolism, Bioresources and Bioprocessing, 2020, 7, 5

[2]         Zhen Zhang, Yingying Tan, Weiliang Wang, Wenmin Bai, Jianhua Fan, Jianke Huang, Minxi Wan*(通讯作者), Yuanguang Li*, Efficient heterotrophic cultivation of Chlamydomonas reinhardtii. Journal of applied phycology, 2019,31(3): 1545–1554

[3]         Haohua Wang, Zhen Zhang, Minxi Wan*(通讯作者),, Ruixuan Wang, Jianke Huang, Kaikai Zhang, Jiacai Guo, Wenmin Bai, Yuanguang Li*, Comparative study on light attenuation models of Galdieria sulphuraria for efficient production of phycocyanin, Journal of applied phycology, 2019, 32, 165–174

[4]         Minxi Wan, Zhen Zhang*, Ruixuan Wang, Wenmin Bai, Jianke Huang, Weiliang Wang, Guomin Shen, Anquan Yu, Yuanguang Li*, High-yield cultivation of Botryococcus braunii for biomass and hydrocarbons, Biomass and Bioenergy, 2019, 131, 105399

[5]       Lei Fang, Jingkui Zhang, Zhongnan Fei, Minxi Wan*(通讯作者), Chlorophyll as key indicator to evaluate astaxanthin accumulation ability of Haematococcus pluvialis, Bioresources and Bioprocessing, 2019, 6, 52

[6]       Weiliang Wang, Tingting Wei, Jianhua Fan, Jun Yi, Yuanguang Li*, Minxi Wan*(通讯作者), Jun Wang, Wenmin Bai. Repeated mutagenic effects of 60Co-γ irradiation coupled with high-throughput screening improves lipid accumulation in mutant strains of the microalgae Chlorella pyrenoidosa as a feedstock for bioenergy. Algal Research, 2018, 33:71-77

[7]       Bin Sheng, Fei Fan, Jianke Huang, Wenmin Bai, Jun Wang, Sulan Li, WeiLi, Minxi Wan*(通讯作者), Yuanguang Li*. Investigation on models for light distribution of Haematococcus pluvialis during astaxanthin accumulation stage with an application case. Algal Research, 2018, 33:182-189

[8]       Minxi Wan, Zhenyang Wang, Zhen Zhang, Jun Wang, Shulan Li, Anquan Yu, Yuanguang Li*. A novel paradigm for the high-efficient production of phycocyanin from Galdieria sulphuraria. , Bioresource Technology, 2016, 218: 272-278

[9]       Dongda Zhang*#, Minxi Wan#(并列一作), Ehecatl A. del Rio-Chanona, Jianke Huang, Weiliang Wang, Yuanguang Li, Vassilios S. Vassiliadis*. Dynamic Modelling of Haematococcus pluvialis Photoinduction for Astaxanthin Production in both Attached and Suspended Photobioreactors, Algal Research, 2016, 13: 69-78

[10]   Minxi Wan#, Zhen Zhang#, Jun Wang, Jianke Huang, Jianhua Fan, Anquan Yu, Weiliang Wang, Yuanguang Li*. Sequential Heterotrophy–Dilution–Photoinduction Cultivation of Haematococcus pluvialis for efficient production of astaxanthin, Bioresource Technology, 2015, 198: 557-563

[11]   Minxi Wan, Jingkui Zhang, Dongmei Hou, Jianhua Fan, Yuanguang Li *, Jianke Huang, Jun Wang, The effect of temperature on cell growth and astaxanthin accumulation of Haematococcus pluvialis during a light-dark cyclic cultivation. Bioresource Technology, 2014, 167(8):1958-1964

[12]   Minxi Wan, Xuejie Jin, Jinlan Xia *, Julian N. Rosenberg, Geng Yu, Zhenyuan Nie, George A. Oyler, Michael J. Betenbaugh *. The effect of iron on growth, lipid accumulation, and gene expression profile of the freshwater microalga Chlorella sorokiniana. Applied Microbiology and Biotechnology, 2014, 98(22):9473-9481

[13]   Minxi Wan#, Dongmei Hou#, Yuanguang Li*, Jianhua Fan, Jianke Huang, Songtao Liang, Weiliang Wang, Ronghua Pan, Jun Wang, Shulan Li. The effective photoinduction of Haematococcus pluvialis for accumulating astaxanthin with attached cultivation. Bioresource Technology, 2014, 163(4), 26-32 

[14]   Minxi Wan, Junaid Faruq, Julian N. Rosenberg, Jinlan Xia, George A. Oyler, Michael J. Betenbaugh. Achieving high throughput sequencing of cDNA library utilizing an alternative protocol for the bench top next-generation sequencing system. Journal of Microbiological Methods, 2013, 92(2):122-126

[15]   Minxi Wan, Runmin Wang, Jinlan Xia*, Julian N. Rosenberg, George A. Oyler, Michael J. Betenbaugh. Physiological evaluation of a new Chlorella sorokiniana isolate for its biomass production and lipid accumulation in photoautotrophic and heterotrophic cultures. Biotechnology and Bioengineering, 2012, 109(8):1958-1964

[16]   Minxi Wan, Peng Liu, Jinlan Xia*, Julian N. Rosenberg, George A. Oyler, Michael J. Betenbaugh, Zhenyuan Nie, Guanzhou Qiu. The effect of mixotrophy on microalgal growth, lipid content, and expression levels of three pathway genes in Chlorella Sorokiniana. Applied Microbiology and Biotechnology, 2011, 91:835–844

[17]   Minxi Wan, Julian N. Rosenberg, Junaid Faruq, Michael J. Betenbaugh, Jinlan Xia. An improved colony PCR procedure for genetic screening of Chlorella and related microalgae. Biotechnology Letters, 2011, 33:1615–1619

[18]     Minxi Wan, Yu Yang, Guanzhou Qiu*, Ailin Xu, Lin Qian, Zhiying Huang, Jinlan Xia. Acidophilic bacterial community reflecting pollution level of sulphide mine impacted by acid mine drainage. Journal of Central South University of Technology, 2009, 16: 02230229

[19]   Minxi Wan, Yu Yang, Weimin Zeng, Jinlan Xia, Xueduan Liu, Wenqin Qin, Guanzhou Qiu*. Succession of Bacterial Community Inhabited Acid Mine Drainage under High Fe(II) Concentration. Journal of Environmental Science and Engineering, 2010, 4(8): 46-55

[20]   Feifei Han, Weiliang Wang, Yuanguang Li*, Guomin Shen, Minxi Wan*(通讯作者), Jun Wang. Changes of biomass, lipid content and fatty acids composition under a light-dark cyclic culture of Chlorella pyrenoidosa in response to different temperature. Bioresource technology, 2013, 132:182-189

 

发明专利:

申请中国发明专利6项、国外发明专利5项。

 

联系方式:上海市梅陇路130号实验181101Tel:18621924712

E-mailwanminxi@ecust.edu.cn