宫衡
发布人:2020十大正规网赌网址网站管理员  发布时间:2016-10-19   动态浏览次数:7173

宫衡

生物工程专业:博士生导师/硕士生导师
微生物学专业:硕士生导师
生物与医药工程领域:工程硕士导师

    

江苏镇江人,博士、教授。198589 年,于无锡轻工业学院现改名江南大学),获发酵工程工学学士学位;并于1994在该校获发酵工程工学博士学位。1995年至今,在全球十大网赌排行app从事教学和科研工作,期间于2000年至02年于日本大阪大学生物工程国际交流中心进行博士后研究。教学方面,主讲课程《发酵工程》为国家精品课程。研究方面主要从事微生物产品的开发,实施的多项产品技术水平处于国内领先;其中生物法1,3-丙二醇生产技术建成了国内首套万吨级的产业化装置

 

研究方向:

 

1 发酵过程工程:

    结合微生物营养需求与产物代谢的特点,通过过程优化与放大,以实现大规模水平上发酵过程的稳定与高效。

2 应用分子生物学:

    利用生物信息学和现代分子生物学方法手段,研究微生物的代谢调节及产物合成的机制。

3 生物检测

    主要利用表面增强拉曼光谱(SRES)实现生物样品的快速检测。

 

代表性论文(*通讯作者):

 

1.    Bao, W., Wei, R., Liu, X., Dong, S., Chen, T., Fu, S., and Gong, H.*, Regulation of Pyruvate Formate Lyase-Deficient Klebsiella pneumoniae for Efficient 1,3-Propanediol Bioproduction. Curr Microbiol, 2020. 77(1): p. 55-61.

2.    Xu, D., Jia, Z., Zhang, L., Fu, S., and Gong, H.*, Analysis of the Growth and Metabolites of a Pyruvate Dehydrogenase Complex- Deficient Klebsiella pneumoniae Mutant in a Glycerol-Based Medium. J Microbiol Biotechnol, 2020. 30(5): p. 753-761.

3.    Zhang, L., Bao, W., Wei, R., Fu, S., and Gong, H.*, Inactivating NADH:quinone oxidoreductases affects the growth and metabolism of Klebsiella pneumoniae. Biotechnol Appl Biochem, 2018. 65(6): p. 857-864.

4.    Zhang, Y., Jia, Z., Lin, J., Xu, D., Fu, S., and Gong, H.*, Deleting pck improves growth and suppresses by-product formation during 1,3-propanediol fermentation by Klebsiella pneumoniae. J Appl Microbiol, 2017. 123(3): p. 678-687.

5.    Huang, Y., Gu, J., Xiang, G., Xu, J., Fu, S., and Gong, H.*, Detection of total protein in milk using phosphomolybdic acid-mediated surface-enhanced Raman spectroscopy. Journal of Raman Spectroscopy, 2016. 47(3): p. 277-282.

6.    Jiang, X., Zhu, C., Lin, J., Li, J., Fu, S., and Gong, H.*, Vector promoters used in Klebsiella pneumoniae. Biotechnol Appl Biochem, 2016. 63(5): p. 734-739.

7.    Lin, J., Zhang, Y., Xu, D., Xiang, G., Jia, Z., Fu, S., and Gong, H.*, Deletion of poxB, pta, and ackA improves 1,3-propanediol production by Klebsiella pneumoniae. Appl Microbiol Biotechnol, 2016. 100(6): p. 2775-84.

8.    Li, M., Chen, J., Xu, J., Fu, S., and Gong, H.*, Determination of Lactose in Milk by Raman Spectroscopy. Analytical Letters, 2015. 48(8): p. 1333-1340.

9.    Zhu, C., Jiang, X., Zhang, Y., Lin, J., Fu, S., and Gong, H.*, Improvement of 1,3-propanediol production in Klebsiella pneumoniae by moderate expression of puuC (encoding an aldehyde dehydrogenase). Biotechnol Lett, 2015. 37(9): p. 1783-90.

10.  Cui, Y.L., Zhou, J.J., Gao, L.R., Zhu, C.Q., Jiang, X., Fu, S.L., and Gong, H.*, Utilization of excess NADH in 2,3-butanediol-deficient Klebsiella pneumoniae for 1,3-propanediol production. J Appl Microbiol, 2014. 117(3): p. 690-8.

11.  Gao, L.R., Jiang, X., Fu, S.L., and Gong, H.*, In silico identification of potential virulence genes in 1,3-propanediol producer Klebsiella pneumonia. J Biotechnol, 2014. 189(10): p. 9-14.

12.  Zhong, Z.H., Liu, L.F., Zhou, J.J., Gao, L.R., Xu, J.J., Fu, S.L., and H., G*. Influences of 3-hydroxypropionaldehyde and lactate on the production of 1,3-propanediol by Klebsiella pneumoniae. Bioresources and Bioprocessing, 2014. 1,  DOI: 10.1186/s40643-014-0002-z.

13.  Xiang, G., Li, J., Duan, J., Shao, F., Xu, J., Fu, S., and Gong, H.*, Acceleration effect of amino acid supplementation on glycerol assimilation by Escherichia coli in minimal medium. Biotechnol Lett, 2013. 35(9): p. 1495-500.

14.  Xu, J., Turner, J.W., Idso, M., Biryukov, S.V., Rognstad, L., Gong, H., Trainer, V.L., Wells, M.L., Strom, M.S., and Yu, Q., In situ strain-level detection and identification of Vibrio parahaemolyticus using surface-enhanced Raman spectroscopy. Anal Chem, 2013. 85(5): p. 2630-7.

15.  Zhang, L., Xu, J., Mi, L., Gong, H., Jiang, S., and Yu, Q., Multifunctional magnetic-plasmonic nanoparticles for fast concentration and sensitive detection of bacteria using SERS. Biosensors & Bioelectronics, 2012. 31(1): p. 130-6.

16.  Xu, J., Kvasnicka, P., Idso, M., Jordan, R.W., Gong, H., Homola, J., and Yu, Q., Understanding the effects of dielectric medium, substrate, and depth on electric fields and SERS of quasi-3D plasmonic nanostructures. Opt Express, 2011. 19(21): p. 20493-505.

17.  Xu, J., Zhang, L., Gong, H., Homola, J., and Yu, Q., Tailoring plasmonic nanostructures for optimal SERS sensing of small molecules and large microorganisms. Small, 2011. 7(3): p. 371-6.

18.  Xu, J.J., Guan, P., Kvasnicka, P., Gong, H., Homola, J., and Yu, Q.M., Light Transmission and Surface-Enhanced Raman Scattering of Quasi-3D Plasmonic Nanostructure Arrays with Deep and Shallow Fabry-Perot Nanocavities. Journal of Physical Chemistry C, 2011. 115(22): p. 10996-11002.

19.  Yu, Q., Braswell, S., Christin, B., Xu, J., Wallace, P.M., Gong, H., and Kaminsky, D., Surface-enhanced Raman scattering on gold quasi-3D nanostructure and 2D nanohole arrays. Nanotechnology, 2010. 21(35): p. 355301.

 

发明专利:

 

1.  宫衡, 陈天宇, and 付水林, 一种调控生长速度筛选1,3-丙二醇生产菌株的方法.中国发明专利:2020104167201

2.  宫衡, 刘旭霞, and 付水林, 一种可靠、稳定生产多元醇的方法.中国发明专利:2020105259662

3.  宫衡, 魏仁全, and 付水林, 一种降低1,3-丙二醇生产过程中副产物的方法.中国发明专利:2020107925827

4.  宫衡, 暴文静, and 付水林, 强化丙酮酸脱氢酶途径高效生产1,3-丙二醇的方法.中国发明专利:2019105577535

5.  宫衡, 张利娟, and 傅水林, 一种高效合成多元醇的新方法.中国发明专利:2018108343046

6.  宫衡, 徐丹凤, and 傅水林, 一种同时生物合成1,3丙二醇和乙偶姻的新方.中华人民共和国国家知识产权局:2017102753432

7.  宫衡, 张永强, and 傅水林, 一种改进1,3-丙二醇生物合成的方法.中国发明专利:

8.  宫衡, 黄英钊, and 付水林, 一种快速检测牛奶中总蛋白的方法.中国发明专利:201510181955.6

9.  宫衡, 林杰, and 付水林, 一种通过降低副产物乙酸高效生产1,3-丙二醇的方法中国发明专利: 201510621014.X

 

联系方式:

地点:上海市徐汇区梅陇路130号,华东理工大学实验五楼211

邮编:200237
 Tel
 021-64253007
 Email
gongheng@ecust.edu.cn